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When energy is needed, white adipose tissue (WAT) provides fatty acids (FA) for use in peripheral tissues via stimulation of fat cell lipolysis. FA have been postulated to play a critical role in the development of obesity-induced insulin resistance, a major risk factor for diabetes and cardiovascular disease. However, whether and how chronic inhibition of fat mobilization from WAT modulates insulin sensitivity remains elusive. Hormone-sensitive lipase (HSL) participates in th...

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ea0041oc12.3 | Obesity | ECE2016

Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on circulating pro-neurotensin in the Diet, Obesity, and Genes (DiOGenes) Study: a randomized, controlled trial

Rudovich Natalia , Bernigau Wolfgang , Pivovarova Olga , Osterhoff Martin , Sparwasser Andrea , Bergmann Andreas , Struck Joachim , van Baak Marleen A , Jebb Susan A , Papadaki Angeliki , Alfredo Martinez J , Handjieva-Darlenska Teodora , Kunesova Marie , Hager Jorg , Valsesia Armand , Viguerie Nathalie , Langin Dominique , Astrup Arne , Saris Wim H M , Pfeiffer Andreas F H

Aims: Elevated levels of neurotensin (NT), a neurotransmitter and postprandial secreted intestinal hormone, are associated with an increased risk of diabetes, cardiovascular disease and breast cancer. Here we studied the regulation of circulating pro-NT (a stable NT precursor fragment) by weight loss and dietary interventions.Methods: DiOGenes is a pan-European controlled dietary intervention study in overweight adults who first lost body weight on an 8-...

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Endocrine Abstracts

Adipose tissue lipolysis and insulin sensitivity

Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on circulating pro-neurotensin in the Diet, Obesity, and Genes (DiOGenes) Study: a randomized, controlled trial

BiosciAbstracts